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HRP-0814 Recombinant Human XPNPEP1 Protein $300

Recombinant Human XPNPEP1 Protein

Product Name: Recombinant Human XPNPEP1 Protein
Catalog #:  HRP-0814
Manufacture:  LD Biopharma, Inc.

Human xaa-pro aminopeptidase 1 (XPNPEP1) encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants. This gene SNP mapping indicated that XPNPEP1 are associated with both late-onset Alzheimer disease and angiotensin-converting enzyme inhibitor-induced cough.

Full-length human XPNPEP1 (666 aa) gene was constructed with 19 aa N-terminal T7 tag and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Accession Number:  NP_065116
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Cilia La Corte,A.L., et al., The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst 9 (4), 221-225 (2008).
Li,X., et al., Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. J. Biol. Chem. 283 (33), 22858-22866 (2008).
Vanhoof,G., et al., Kininase activity in human platelets: cleavage of the Arg1-Pro2 bond of bradykinin by aminopeptidase P. Biochem. Pharmacol. 44 (3), 479-487 (1992).

1. May be used for in vitro peptide hormones modification regulation study with intracellular protein delivery of this protein.

2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.

3. May be used for mapping XPNPEP1 protein-protein interaction.

4. As potential diagnostic biomarker for both late-onset Alzheimer disease and angiotensin-converting enzyme related diseases.

Quality Control: 1. Purity: > 90% by SDS-PAGE.
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