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| Cata #: | Name of Product: | Price: |
| HTF-3444 | Recombinant YFP-Human TOX3-11R Protein | $300 |
| Product Name: | Recombinant YFP-Human TOX3-11R Protein |
| Catalog #: | HTF-3444 |
| Manufacture: | LD Biopharma, Inc. |
| Intruduction: | Human TOX high mobility group box family member 3 (TOX3) gene encodes a transcriptional co-activator of the p300/CBP-mediated transcription complex. It activates transactivation through cAMP response element (CRE) sites. Tox3 protects against cell death by inducing anti-apoptotic and repressing pro-apoptotic transcripts. It stimulates transcription from the estrogen-responsive or BCL-2 promoters. It is required for depolarization-induced transcription activation of the C-FOS promoter in neurons. It is associates with chromatin to the estrogen-responsive C3 promoter region. Mutation of human Tox3 gene have been linked to various cancers such as breast or ovarian cancers. Full-length human Tox3 cDNA (575aa, derived from BC167799) was constructed with codon optimization gene synthesis and expressed with YFP Protein as N-terminal (YFP; 256aa) fusion protein in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | Tox3 (CAGF9; TNRC9) |
| Accession Number: | NP_001073899 |
| Species: | Human |
| Package Size: | 50µg / Vial |
| Composition: | 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least two weeks. |
| Key Reference: | Sanjeeb Kumar Saha, et al.Txo3 regulates neural progenitor identity. Biochim Biophys acta Jul; 1859(7): 833-40,(2016) Jones JO, et al.Txo3 mutation in breast cancer. PLos One.Sep 19;8(9);e74102.(2013) O'Flaherty E and Kaye J. TOX defines a conserved subfamily of HMG-box proteins. BMC Genomics 4 (1), 13 (2003) |
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| Recombinant Protein Sequence: | MKHHHHHHQVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKLLCTTGKLPVPWPTLVTTLGYGVQCFARYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYITADKQKNGIKANFKIRHNIEDGGVQLADHYQQNTPIGDGPVLLPDNHYLSYQSALFKDPNEKRDHMVLLEFLTAAGITEGMNELYKRSDVRFYPAAAGDPASLDFAQCLGYYGYSKFGNNNNYMNMAEANNAFFAASEQTFHTPSLGDEEFEIPPITPPPESDPALGMPDVLLPFQALSDPLPSQGSEFTPQFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQDPSLIMRSIVHMTDAARSGVMPPAQLTTINQSQLSAQLGLNLGGASMPHTSPSPPASKSATPSPSSSINEEDADEANRAIGEKRAAPDSGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASLVSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQHGTVSASPQTLQQSLPRSIAPKPLTMRLPMNQIVTSVTIAANMPSNIGAPLISSMGTTMVGSAPSTQVSPSVQTQQHQMQLQQQQQQQQQQMQQMQQQQLQQHQMHQQIQQQMQQQHFQHHMQQHLQQQQQHLQQQINQQQLQQQLQQRLQLQQLQHMQHQSQPSPRQHSPVASQITSPIPAIGSPQPASQQHQSQIQSQTQTQVLSQVSIFESGGGGSPGRRRRRRRRRRR |