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HRP-3408 Recombinant Human PCDH19 Protein $300

Recombinant Human PCDH19 Protein

Product Name: Recombinant Human PCDH19 Protein
Catalog #:  HRP-3408
Manufacture:  LD Biopharma, Inc.

Human protocadherin-19 (PCDH19) gene encodes a cell-membrane protein which is potential calcium-dependent cell-adhesion protein. Recent data indicated that dysfunction of PCDH19 cause trouble when mossy fibers of the brain are forming synapses. Although PCDH19 locus was on X chromosome, mutations in the PCDH19 gene cause cognitive impairment, affecting females more than males. 

Full-length extracellular domain of human PCDH19 cDNA ( 26 – 678aa, Isoform-I ) was constructed with codon optimization gene synthesis and expressed with a human alpha Fetal Protein N-terminal (AFPn) -His-TEV cleavage site Tag (217aa) fusion at its N-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  PCDH19 ( KIAA1313 ) 
Accession Number:  NP_001171809
Species:  Human
Package Size:  75 µg / Vial   
Composition: 1.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference:

Naosuke Hoshina, et al. Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder. Science. Vol 372, Issue 6539, eaaz 3893. (2021)

  1. May be used for in vitro PCDH19 mediated neuronal cell differentiation (synapses formation) regulation study in vitro for various cells with this recombinant PCDH19 protein either as soluble factor or as coating matrix protein. 
  2. May be used for PCDH19 protein-protein interaction assay.
  3. As native human PCDH19 antigen for specific antibody production.
Quality Control: Purity: > 92 % by SDS-PAGE.
Recombinant Protein Sequence:


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