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HRP-3156 Recombinant YFP-Human Rab11b Fusion Protein $300

Recombinant YFP-Human Rab11b Fusion Protein

Product Name: Recombinant YFP-Human Rab11b Fusion Protein
Catalog #:  HRP-3156
Manufacture:  LD Biopharma, Inc.

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The human Ras-related protein Rab-11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. It may also regulate constitutive and regulated secretion, like insulin granule exocytosis. It is required for melanosome transport and release from melanocytes. Rab11B also regulates V-ATPase intracellular transport in response to extracellular acidosis. Recent data indicated that Rab11B mediated integrin recycling which promote brain cancer cells metastatic adaptation and outgrowth. 

Full-length mature form of human Rab11b cDNA (2 - 215aa) was constructed with codon optimization gene synthesis and expressed with YFP Protein as N-terminal (YFP; 256aa) fusion protein in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  Rab11b ( YPT3 ) 
Accession Number:  NP_004209
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least two weeks.
Key Reference:

Howe, E.N., et al. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth.Nature Communi. 10.1038 /s41467-020-16832-2. (2020) 

Zulkefli KL, et al., A role for Rab11 in the homeostasis of the endosome-lysosomalpathway. Exp. Cell Res. 380 (1), 55-68 (2019)

  1. May be used for in vitro Rab11b protein mediated integrin recycling pathway regulation for brain tumor metastatic study using intracellular delivery of recombinant human Rab11b protein with protein delivery reagent such as ProFectin. 
  2. May be used for Rab11b protein-protein interaction assay.
  3. May be used as specific substrate protein for Rab11b specific kinase, and ubiquitin (Sumo pathway) related enzyme functional screening assays.
  4. Potential therapeutic protein, blocking Rab11b may regulates integrin recycling efficiency, which benefits brain tumor treatment. 
  5. As native human Rab11b immunogen for its specific antibody production.
Quality Control: Purity: > 90 % by SDS-PAGE.
Recombinant Protein Sequence:


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