Invention in the REGENERATIVE MEDICINE is what we do every day, benefits of patients is our final goal

Our Products

Home > Products

Cata #: Name of Product: Price:
HTF-2838 Recombinant Human TOX-11R Protein $250

Recombinant Human TOX-11R Protein

Product Name: Recombinant Human TOX-11R Protein
Catalog #:  HTF-2838
Manufacture:  LD Biopharma, Inc.

Human Thymocyte Selection-Associated High Mobility Group Box Protein TOX gene encodes a transcription factor. TOX protein contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. TOX function regulates T-cell development, especially in controlling CD8+ T cell exhaustion during chronically infection.


Full-length human TOX cDNA (525aa, derived from BC016665) was constructed with codon optimization using gene synthesis technology and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal and 11 arginine (11R) tag at its C-terminal. It was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  

TOX                (  TOX1  )

Accession Number:  NP_055544
Species:  Human
Package Size:  30 µg / Vial   
Composition: 0.3 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose ,DTT and others.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least two weeks.
Key Reference:

Omar Khan, et al.,TOX trabscriptionally and epigenetically programs CD8+ T cell exhaustion. Nature. (2019) 

Lobbardi R,et al.,TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia. Cancer Discov 7 (11), 1336-1353 (2017)

Benoit BM, et al., CD164 identifies CD4(+) T cells highly expressing genes associated with malignancy in Sezary syndrome: the Sezary signature genes, FCRL3, Tox, and miR-214. Arch. Dermatol. Res. 309 (1), 11-19 (2017)

  1. May be used for in vitro TOX mediated gene transcription regulation study in T cell cell’s differentiation by intracellular delivery of this TOX-11R protein directly in vitro cell culture.
  2. May be used for mapping TOX protein-protein interaction.
  3. May be used as specific substrate protein for kinase, and ubiquitin (Sumo pathway) related enzyme functional screening assays.
  4. Potential biomarker protein / therapeutic target protein for T cell function related diseases, such as controlling T cell activities in vivo, et al.
  5. As native Human TOX immunogen for its specific antibody production.
Quality Control: Purity: > 90 % by SDS-PAGE.
Recombinant Protein Sequence:


Download Datasheet