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HTF-2249 Recombinant Human cJun-11R Protein $300

Recombinant Human cJun-11R Protein

Product Name: Recombinant Human cJun-11R Protein
Catalog #:  HTF-2249
Manufacture:  LD Biopharma, Inc.

Human transcription factor AP-1 (also named as c-Jun) gene encodes a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Recent data indicated that c-Jun overexpression in CAR-T cells induces exhaustion resistance.


Full-length human C-Jun cDNA (330aa, derived from BC068522) was constructed with codon optimization using gene synthesis technology and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal and 11 arginine (11R) tag at its C-terminal. It was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  

C-Jun               ( AP1, c-Jun; p39 )

Accession Number:  NP_057953.1
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose ,DTT and others.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least two weeks.
Key Reference:

Rachel C Lynn, et al., C-jun overexpression in CAR-T cells induces exhaustion resistance. Nature. (2019)


Addison WN, et al., Dephosphorylation of the transcriptional cofactor NACA by the PP1A phosphatase enhances cJUN transcriptional activity and osteoblast

 Differentiation. J. Biol. Chem. 294 (20), 8184-8196 (2019)


 Yoon H, et al., p27 transcriptionally coregulates cJun to drive programs of tumor progression. Proc. Natl. Acad. Sci. U.S.A. 116 (14), 7005-7014 (2019)

  1. May be used for in vitro c-Jun mediated gene transcription regulation study in B cell or neuronal cell’s differentiation by intracellular delivery of this cJun-11R protein directly in vitro cell culture.
  2. May be used for mapping c-Jun protein-protein interaction.
  3. May be used as specific substrate protein for kinase, and ubiquitin (Sumo pathway) related enzyme functional screening assays.
  4. Potential biomarker protein / therapeutic target protein for modulating CAR-T cell activities, such as overcome CAR-T cell exhaustion.
  5. As native human c-Jun immunogen for specific antibody production.
Quality Control: Purity: > 92 % by SDS-PAGE.

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