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MRP_2609 Recombinant Malaria PMIF Protein $300

Recombinant Malaria PMIF Protein

Product Name: Recombinant Malaria PMIF Protein
Catalog #:  MRP_2609
Manufacture:  LD Biopharma, Inc.

Malaria is the second leading cause of infectious disease worldwide and took close to a half-million lives in 2016. To develop an effective vaccine for blocking malaria infection, Yale university scientists recently described a unique protein produced by malaria parasites, Plasmodium macrophage migration inhibitory factor (PMIF), which suppresses memory T cells, the infection-fighting cells that respond to threats and protect the body against re-infection. In animal model, vaccinated using mRNA based intracellular delivery of PMIF demonstrate a good protective effects against malaria infection.


To develop a unique protein based intracellular delivery system for testing malaria vaccine, a full-length Malaria PMIF encoding gene was constructed with codon optimization and expressed with N terminal human Alpha Fetal Protein Tag (217aa)  and C-terminal 11 arginine (11R tag) fusion as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  Malaria PMIF 
Accession Number:  PF3D7_1229400
Species:  Plasmodium Falciparum
Package Size:  25 µg / Vial   
Composition: 0.25 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT, and others.
Storage: In liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 7 days.
Key Reference:

Alvaro Baeza Garcia, et al., Neutralization of the plasmodium-encoded MIF ortholog confers protective immunity against malaria infection. Nature communication. DOI: 10.1038/s41467-018-05041-7. (2018).

  • May be used for study PMIF mediated anti-malaria immune-response in vitro using recombinant PMIF-11R fusion protein through direct intracellular protein delivery pathway.
  • High purified malaria PMIF protein, which may be used for specific antibody production.
Quality Control: Purity: > 92 % by SDS-PAGE.
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