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RAB-2563 Recombinant Anti-Human CD19 scFv Antibody $300

Recombinant Anti-Human CD19 scFv Antibody

Product Name: Recombinant Anti-Human CD19 scFv Antibody
Catalog #:  RAB-2563
Manufacture:  LD Biopharma, Inc.

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. Human CD19 gene encodes a cell surface molecule, which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Anti-CD19 antibody has been used for purification B cell or targeting B cell derived lymphoma, such as anti-CD19 single chain antibody mediated chimeric antigen receptor modified T cell ( CAT-T) technology.
Anti-human CD19 specific Single Chain Variable Fragment Antibody (clone SJ25C1): scFv. (Human H-link-L single chain format) gene was constructed with codon optimization gene synthesis and expressed with a human Alpha Fetal Protein N-terminal (AFPn) -His-TEV cleavage site Tag (217aa) fusion at its N-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  Anti-Human CD19 scFV 
Accession Number:  SJ25C1
Species:  Mouse hybridoma derived
Package Size:  20 µg / Vial   
Composition: 0.2 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others.
Storage: In liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Kochenderfer,J.N., et al., Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor J. Immunother. 32 (7), 689-702 (2009)
Kochenderfer,J.N., et al., Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19. Blood 116 (20), 4099-4102 (2010)
  1. Highly purified anti - human CD19 recombinant single chain antibody, excellent reagent for detection of human CD19 in ELISA or western blot assay.
  2. Excellent antigen for generating anti-human CD19 scFv ( SJ25C1) antibody
Quality Control: Purity: > 90 % by SDS-PAGE.
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