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VRP-2017 Recombinant Human integrin a5b6 Binding Protein-I $300

Recombinant Human integrin a5b6 Binding Protein-I

Product Name: Recombinant Human integrin a5b6 Binding Protein-I
Catalog #:  VRP-2017
Manufacture:  LD Biopharma, Inc.

Human integrin a5b6, a member of the integrin family, is specifically expressed in many malignancies but not in normal organs. Generation of integrin a5b6, specific binding moiety has been demonstrated potential clinical applications, such as specific human integrin a5b6, binding peptide P2: NAVPNLRGDLQVLAQKVART, which derived from foot-and-mouth disease virus was used as radiotracer for tumor image in vivo. Using flow cytometry and ELISA assay, this P2 peptide was demonstrated to have a highly selective, inhibiting a5b6-ligand binding with a IC50 of 3 nmol/L, an activity 1,000-fold more selective for a5b6 than for other RGD-directed integrins (avb3, avb5, and avb1).

A peptide of P2 NAVPNLRGDLQVLAQKVART was constructed with codon optimization gene synthesis and expressed with a human Alpha Fetal protein at N-terminal. This protein was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  P2 peptide 
Accession Number:  None
Species:  Human AFPn and foot-and-mouth disease virus derived peptide
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Kraft S, et al. Definition of an unexpected ligand recognition motif for alphav beta6 integrin. Journal of Biological Chemistry 274(4):1979-1985 (1999)
Quality Control: Purity: > 90% by SDS-PAGE.
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