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HRP-2311 Recombinant Human CXCL2 Protein $300

Recombinant Human CXCL2 Protein

Product Name: Recombinant Human CXCL2 Protein
Catalog #:  HRP-2311
Manufacture:  LD Biopharma, Inc.

Human C-X-C chemokine 2 (CXCL2) is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 is a hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta (5-73) shows a highly enhanced hematopoietic activity. Recent data indicated that CXCL2 may also plays a role in human obesity development by regulating adipose tissue infiltration macrophage.

Full-length mature human CXCL2 ( GRO-beta ) cDNA ( 39 - 107aa ) was constructed with fully codon optimization strategy with N-terminal human AFP protein / TEV cleavage site as tag fusion. This protein was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CXCL2 (GRO2; MGSA-b; MIP-2a; CINC-2a) 
Accession Number:  NP_002080.1
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Al-Alwan LA, et al., Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration. J. Immunol. 191 (5), 2731-2741 (2013)
Rouault C, et al., Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. Endocrinology 154 (3), 1069-1079 (2013)
King AG, Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities. J. Immunol. 164 (7), 3774-3782 (2000)

1. May be used for in vitro CXCL2 mediated hemato regulation study for hematopoietic stem cells with this protein either as soluble factor or as coating matrix protein.

3. As immunogen for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE.
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