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HRP-1981 Recombinant Human FABP4 Protein $300

Recombinant Human FABP4 Protein

Product Name: Recombinant Human FABP4 Protein
Catalog #:  HRP-1981
Manufacture:  LD Biopharma, Inc.

The fatty-acid-binding proteins (FABPs) are a family of transport proteins for fatty acids and other lipophilic substances such as eicosanoids and retinoids. These proteins are thought to facilitate the transfer of fatty acids between extra- and intracellular membranes. Some family members are also believed to transport lipophilic molecules from outer cell membrane to certain intracellular receptors such as PPAR. Levels of fatty-acid-binding protein have been shown to decline with ageing in the mouse brain, possibly contributing to age-associated decline in synaptic activity. FABP4 protein is dominantly expressed in adipocytes, as lipid transport protein. It binds both long chain fatty acids and retinoic acid. FABP4 delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.

Full-length of human FABP4 cDNA (131aa ) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (31aa) fusion at its N-terminal. It was expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  FABP4 (A-FABP; ALBP; aP2; HEL-S-104) 
Accession Number:  NP_001433.1
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Alqahtani MF, et al., Evaluation of New Diagnostic Biomarkers in Pediatric Sepsis: Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, Mid-Regional Pro-Atrial Natriuretic Peptide, and Adipocyte Fatty-Acid Binding Protein. PLoS ONE 11 (4), E0153645 (2016)
Zhang S, et al., Circulating Adipocyte Fatty Acid Binding Protein (FABP4) Levels Are Associated with Irisin in the Middle-Aged General Chinese Population. PLoS ONE 11 (1), E0146605 (2016)
Saavedra P, et al., New insights into circulating FABP4: Interaction with cytokeratin 1 on endothelial cell membranes. Biochim. Biophys. Acta 1853 (11 PT A), 2966-2974 (2015)
Reiser H, et al., Circulating FABP4 is a prognostic biomarker in patients with acute coronary syndrome but not in asymptomatic individuals. Arterioscler. Thromb. Vasc. Biol. 35 (8), 1872-1879 (2015)

1. May be used for in vitro FABP4 mediated long-chain fatty acid metabolism regulation study for adipocytes by intracellular delivery of this protein with protein delivery reagent such as ProFectin reagent kit.

2. May be used for mapping protein-protein interaction.

3. May be used as enzymatic substrate for various proteases.

4. Potential biomarker protein for cardiovascular diseases diagnostic applications.

5. As immunogen for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE.
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