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hRP-1821 Recombinant Human CD352 Protein $300

Recombinant Human CD352 Protein

Product Name: Recombinant Human CD352 Protein
Catalog #:  hRP-1821
Manufacture:  LD Biopharma, Inc.

Human SLAM family member 6 (SLAMF6, also named as CD352) gene encodes a member of the CD2 family of cell surface proteins involved in lymphocyte activation. CD352 protein is expressed on (activated or resting) Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a co-receptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

Extracellular domain of human CD352 cDNA ( 22 – 226aa, Isoform-I ) was constructed with codon optimization using gene synthesis technology and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal. This protein was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CD352 (SLAMF6; KALI; KALIb; Ly108; NTB-A; SF2000 
Accession Number:  NP_001171643
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Bolduan S, et al., HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A. Virology 440 (2), 190-203 (2013)
Chatterjee M, et al., CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORgammat recruitment to the IL17A promoter in human T lymphocytes. J. Biol. Chem. 287 (45), 38168-38177 (2012)
Chatterjee M, et al., Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 Differentiation. J. Immunol. 188 (3), 1206-1212 (2012)
Chatterjee M, et al., SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. Autoimmunity 44 (3), 211-218 (2011)

1. May be used for in vitro CD352 mediated T cell activities regulation study in IL17A pathway with this protein either as soluble factor or as coating matrix protein.

2. May be used for protein-protein interaction mapping.

3. Potential biomarker protein for monitoring T cell activity various auto-immuno-diseases.

4. As immunogen for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE.
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