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hRP-1793 Recombinant Human CD89 Protein $200

Recombinant Human CD89 Protein

Product Name: Recombinant Human CD89 Protein
Catalog #:  hRP-1793
Manufacture:  LD Biopharma, Inc.

Human CD89 gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. CD89 interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for human CD89 gene.

Full-length extracellular domain of human CD89 cDNA (22 – 227 aa, derived from BC027953) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal. This protein was expressed in E. coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CD89 (FCAR; CTB-61M7.2; FcalphaRI) 
Accession Number:  NP_001991
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Wehrli M, et al., Human IgA Fc receptor FcalphaRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment. J. Immunol. 193 (11), 5649-5659 (2014)
Chen X, et al., Expression and correlation analysis of IL-4, IFN-gamma and FcalphaRI in tonsillar mononuclear cells in patients with IgA nephropathy Cell. Immunol. 289 (1-2), 70-75 (2014)
Watanabe T, et al., Negative regulation of inflammatory responses by immunoglobulin A receptor (FcalphaRI) inhibits the development of Toll-like receptor-9 signalling-accelerated glomerulonephritis. Clin. Exp. Immunol. 166 (2), 235-250 (2011)
Pleass RJ, et al., Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils. Biochem. J. 318 (PT 3), 771-777 (1996)

1. May be used for in vitro CD89 mediated IgA-opsonized targets activation in inflammation pathway regulation, with this protein either as soluble factor or as coating matrix protein.

2. May be used for protein-protein interaction mapping.

3. Potential biomarker protein for monitoring IgA mediated inflammation pathway status.

4. As immunogen for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE.
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