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hRP-0896 Recombinant Human KHK Protein $300

Recombinant Human KHK Protein

Product Name: Recombinant Human KHK Protein
Catalog #:  hRP-0896
Manufacture:  LD Biopharma, Inc.

Human KHK gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose, which associated with many metabolic states, such as glucose intolerance, hyperlipidaemia, obesity, insulin resistance et al.

Full-length mature human KHK ( 298aa, Isoform-a ) gene was constructed with 15 aa N-terminal T7 tag and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  KHK 
Accession Number:  NP_000212
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Trinh,C.H., et al., Structures of alternatively spliced isoforms of human ketohexokinase. Acta Crystallogr. D Biol. Crystallogr. 65 (PT 3), 201-211 (2009)
Cirillo,P., et al., Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J. Am. Soc. Nephrol. 20 (3), 545-553 (2009)
Hwa,J.S., et al., The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma. Proteomics 6 (3), 1077-1084 (2006)

1. May be used for in vitro KHK mediated fructose metabolism regulation study with “ProFectin” based intracellular delivery of this protein.

2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.

3. May be used for mapping KHK protein-protein interaction.

4. Potential diagnostic biomarker for renal cell carcinoma.

5. May be used as antigen for specific antibody development.

Quality Control: Purity: > 90% by SDS-PAGE.
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