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hRP-0852 Recombinant Human NAA20 Protein $300

Recombinant Human NAA20 Protein

Product Name: Recombinant Human NAA20 Protein
Catalog #:  hRP-0852
Manufacture:  LD Biopharma, Inc.

Human N-alpha-acetyltransferase 20 (NAA20) is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N (alpha)-terminal acetylation of methionine residues when they are followed by asparagine. NatB activities has been linked to regulate mTOR signaling pathway, which involved in many tumorigenesis.

Full-length human NAA20 (178 aa, Isoform-A) gene was constructed with 15 aa N-terminal T7 tag and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  NAA20 (NAT3; NAT5) 
Accession Number:  NP_057184
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Evjenth,R., Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. J. Biol. Chem. 284 (45), 31122-31129 (2009)
Starheim,K.K., et al., Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. Biochem. J. 415 (2), 325-331 (2008)
Jiang,B., et al., Peptide mimic isolated by autoantibody reveals human arrest defective 1 overexpression is associated with poor prognosis for colon cancer patients. Am. J. Pathol. 177 (3), 1095-1103 (2010)

1. May be used for in vitro NatB mediated cell cycle regulation study with intracellular delivery of this protein.

2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.

3. May be used for mapping NAA20 protein-protein interaction.

4. Potential diagnostic biomarker for cancer.

5. May be used as antigen for specific antibody development.

Quality Control: Purity: > 90% by SDS-PAGE.
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