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hRP-0486 Recombinant Human PPIH Protein $300

Recombinant Human PPIH Protein

Product Name: Recombinant Human PPIH Protein
Catalog #:  hRP-0486
Manufacture:  LD Biopharma, Inc.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.

Full length human PPIH gene was constructed with N-terminal 17 aa (T7) tag. This protein was expressed in E. coli as inclusion bodies, refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  PPIH (CYP-20; CYPH; SnuCyp-20; USA_CYP) 
Accession Number:  NP_006338
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Ingelfinger,D., et al,. Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. Nucleic Acids Res. 31 (16), 4791-4796 (2003)
Horowitz,D.S., et al,. A cyclophilin functions in pre-mRNA splicing, EMBO J. 21 (3), 470-480 (2002)

1. May be used for human spliceosome regulation study in vitro,

2. May be used as specific substrate protein for kinase and ubiquitin enzymes.

3. May be used for enzymatic assay

Quality Control: Purity: > 90% by SDS-PAGE.
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