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HRP-1682 Recombinant Human ENDOU Protein $300

Recombinant Human ENDOU Protein

Product Name: Recombinant Human ENDOU Protein
Catalog #:  HRP-1682
Manufacture:  LD Biopharma, Inc.

Human poly(U)-specific endoribonuclease (ENDOU) gene encodes a protein with endoribonuclease & protease activities. It is highly specific expression in the placenta. Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini. This protein may be useful as a tumor marker. Multiple alternatively spliced transcript variants have been found for this protein.

Full-length Human ENDOU cDNA (368aa, Isoform-II, derived from BC074729) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (33aa) fusion at its N-terminal. This protein was expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  ENDOU (P11; PP1; PRSS26) 
Accession Number:  NP_006016
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Laneve P, et al., The tumor marker human placental protein 11 is an endoribonuclease. J. Biol. Chem. 283 (50), 34712-34719 (2008)
Grundmann U, et al., Cloning and expression of a cDNA encoding human placental protein 11, a putative serine protease with diagnostic significance as a tumor marker. DNA Cell Biol. 9 (4), 243-250 (1990)

1. May be used for in vitro ENDOU mediated placenta derived cell & tumor cells differentiation regulations study with this protein as either soluble factor or coating matrix protein.

2. May be used for ENDOU protein-protein interaction mapping.

3. Potential biomarker protein for clinical applications such as monitoring pancreatic cancer progression.

4. As antigen for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE.
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