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HRP-0056 Recombinant Human H2AX Protein $300

Recombinant Human H2AX Protein

Product Name: Recombinant Human H2AX Protein
Catalog #:  HRP-0056
Manufacture:  LD Biopharma, Inc.

H2AX is one of several genes coding for histone H2A. In cells, the DNA .is wrapped around histone-groups, consisting of core histones H2A, H2B, H3 and H4. Thus, the H2AX contributes to the histone-formation and therefore the structure of DNA.


H2AX becomes phosphorylated on serine 139, then called gamma-H2AX, as a reaction on DNA Double-strand breaks (DSB). Gamma-H2AX is a sensitive target for looking at DSBs in cells.


This full-length, non-fusion recombinant human H2AX protein was constructed and expressed in E. coli, refolded using our unique “temperature shift inclusion body refolding” technology and purified chromatographically.


Gene Symbol:  H2AX 
Accession Number:  NP_002096
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -20°C for long term storage. Product is stable at 4 °C for at least 7 days.
Key Reference: Rogakou,E.P., et al. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273 (10), 5858-5868 (1998)

1. Soluble protein which may be used as substrate for enzymatic assay.

2. Active protein, for in vitro histone /DNA reconstitution assay.

3. As Immunogen for specific antibody production.

Quality Control: 1. Purity: > 90% by SDS-PAGE.
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