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HRP-0128 Recombinant Human ACPP-11R Protein $300

Recombinant Human ACPP-11R Protein

Product Name: Recombinant Human ACPP-11R Protein
Catalog #:  HRP-0128
Manufacture:  LD Biopharma, Inc.

PHuman ACPP (acid phosphatase, prostate) gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. This protein was used as human prostate cancer vaccines (Provenge), which FDA accepted in 2010 for treatment of advanced prostate cancer that has metastasis.

Recombinant human ACPP-11R protein was constructed with C-terminal tag of 11 arginine domain, which will efficiently deliver protein intracellularly. This protein was expressed in E. coli, refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. Incubating this protein in various culture media at 2 – 8 µg/ml may be used for studying of human prostate cancer treatment using intracellular protein delivery strategy for immuno-stimulation.

Gene Symbol:  ACPP 
Accession Number:  NP_001090.2 (Isoform 1)
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -20°C for long term storage. Product is stable at 4 °C for at least 7 days
Key Reference: Hongyan Zhou, et al. Generation of induced pluripotent stem cells using recombinant protein. Cell Stem Cell. Vol 4. Issue 5: 381-384 (2009)
MCneel,D.G., et al., Safety and immunological efficacy of a DNA vaccine encoding prostatic acid phosphatase in patients with stage D0 prostate cancer. J.clin.Oncol. 27 (25), 4047-4054. (2009)

1. Human prostate specific tumor antigen.

2. Immunogen for specific antibody production.

Quality Control:

1. Purity: > 90% by SDS-PAGE.

2. Other functional activities: Not tested yet.

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