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HRP-1187 Recombinant Human CLEC14A Protein $150

Recombinant Human CLEC14A Protein

Product Name: Recombinant Human CLEC14A Protein
Catalog #:  HRP-1187
Manufacture:  LD Biopharma, Inc.

Human C-type lectin domain family 14 member A (CLEC14A) gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.

Full-length extracellular domain of human CLEC14A cDNA (22 – 398 aa, derived from BC031567) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal. This protein is expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CLEC14A (C14ORF27; CEG1; EGFR-5) 
Accession Number:  NP_778230
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Mura,M., et al., Identification and angiogenic role of the novel tumor endothelial marker CLEC14A. Oncogene 31 (3), 293-305 (2012)
Zhuang,X., et al., Shear stress, tip cells and regulators of endothelial migration. Biochem. Soc. Trans. 39 (6), 1571-1575 (2011)

1. May be used for in vitro CLEC14A protein mediated tumor endothelial cell formation regulation study with this protein as either coating matrix protein or as soluble factor.

2. May be used for CLEC14A protein – protein interaction assay.

3. May be used as enzymatic substrate for various proteases.

4. May be used for specific antibody production.

Quality Control: Purity: > 90% by SDS-PAGE
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