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HRP-1064 Recombinant Human CD23 Protein $125

Recombinant Human CD23 Protein

Product Name: Recombinant Human CD23 Protein
Catalog #:  HRP-1064
Manufacture:  LD Biopharma, Inc.

The protein encoded by human CD23 gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Full-length extracellular domain of human CD23 cDNA (48 - 321 aa, Isoform_A, derived from BC062591) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (29aa) fusion at its N-terminal and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CD23 (FCER2; CLEC4J; FCE2; IGEBF) 
Accession Number:  NP_001993
Species:  Human
Package Size:  50 µg / Vial   
Composition: 1.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Edkins,A.L., et al., Differential regulation of monocyte cytokine release by alphaV and beta(2) integrins that bind CD23. Immunology 136 (2), 241-251 (2012)
Borthakur,S., et al., Mapping of the CD23 binding site on immunoglobulin E (IgE) and allosteric control of the IgE-Fc epsilonRI interaction. J. Biol. Chem. 287 (37), 31457-31461 (2012)
Edkins,A.L., et al., Analysis of the CD23-alphav integrin interaction: a study with model peptides JOURNAL Biochem. Biophys. Res. Commun. 422 (2), 207-212 (2012)

1. May be used for in vitro human CD23-integrin chain mediated monocyte cytokine regulation study with this protein as either coating matrix protein or soluble factor.

2. May be used for protein-protein interaction assay development.

3. As antigen for specific antibody production.

Quality Control: 1. Purity: > 90% by SDS-PAGE.
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