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HRP-1057 Recombinant Human CD18 Protein $300

Recombinant Human CD18 Protein

Product Name: Recombinant Human CD18 Protein
Catalog #:  HRP-1057
Manufacture:  LD Biopharma, Inc.

The product of human CD18 gene belongs to the integrin b chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin b chain b 2. A given chain may combine with multiple partners resulting in different integrins. For example, b 2 combines with a L chain to form the integrin LFA-1, and combines with the a M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.

Full-length extracellular domain of human CD18 cDNA (23 - 700 aa, derived from BC005861) was constructed with codon optimization and expressed with a small T7-His-TEV cleavage site Tag (31aa) fusion at its N-terminal and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  CD18 (ITGB; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7) 
Accession Number:  NP_000202
Species:  Human
Package Size:  50 ug / Vial   
Composition: 0.20 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Rosetti,F., et al., Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J. Immunol. 189 (7), 3714-3723 (2012)
Jawhara,S., et al., Integrin alphaXbeta(2) is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections. J. Immunol. 189 (5), 2468-2477 (2012)
Verma,N.K., et al., Leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction induces a novel genetic signature resulting in T-cells refractory to transforming growth factor-beta signaling. J. Biol. Chem. 287 (32), 27204-27216 (2012)

1. May be used for in vitro human integrin b chain mediated leukocyte function regulation study with this protein as either coating matrix protein or soluble factor.

2. May be used for protein-protein interaction assay development.

3. As antigen for specific antibody productio

Quality Control: 1. Purity: > 90% by SDS-PAGE.
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