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HRP-0831 Recombinant Human RGS2 Protein $300

Recombinant Human RGS2 Protein

Product Name: Recombinant Human RGS2 Protein
Catalog #:  HRP-0831
Manufacture:  LD Biopharma, Inc.

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 (RGS2) belongs to this family. mRNA profiling of human RGS2 indicated that this gene mainly expressed in CD33+ myeloid, CD14+ monocytes and BDCA4+ dentritic cells. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.

Full-length human RGS2 (211 aa) gene was constructed with 17 aa N-terminal T7 tag and expressed in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified.

Gene Symbol:  RGS2 (G0S8) 
Accession Number:  NP_002914
Species:  Human
Package Size:  50 µg / Vial   
Composition: 0.2 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
Storage: In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Key Reference: Wolff,D.W., et al., Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth. Int. J. Cancer 130 (7), 1521-1531 (2012)
Holden,N.S., et al., beta2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids. Proc. Natl. Acad. Sci. U.S.A. 108 (49), 19713-19718 (2011)
Seredenina,T., et al., Decreased striatal RGS2 expression is neuroprotective in Huntington's disease (HD) and exemplifies a compensatory aspect of HD-induced gene regulation. PLoS ONE 6 (7), E22231 (2011)

1. May be used for in vitro RGS2 mediated tumogenesis pathway regulation study with intracellular delivery of this protein.

2. As soluble / native protein, may be used as enzymatic substrate protein for kinase and ubiquitin assay development.

3. May be used for mapping RGS2 protein-protein interaction.

4. May be used as antigen for specific antibody development.

Quality Control: 1. Purity: > 90% by SDS-PAGE.
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