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| Cata #: | Name of Product: | Price: |
| HRP-3193 | Recombinant Human FIBCD1 ( Fibrinogen Domain ) Protein | $300 |
| Product Name: | Recombinant Human FIBCD1 ( Fibrinogen Domain ) Protein |
| Catalog #: | HRP-3193 |
| Manufacture: | LD Biopharma, Inc. |
| Intruduction: | Human Fibrinogen C domain-containing protein 1 (FIBCD1) gene encodes a single pass type-II membrane protein, which function as acetyl group-binding receptor. It shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. FIBCD1 can facilitate the endocytosis of acetylated components. FIBCD1 mainly expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland. Fibrinogen domain of human FIBCD1 cDNA (235 – 458aa) was constructed with codon optimization gene synthesis and expressed with a SuperGFP Protein N-terminal (sfGFP; 257aa) fusion at target protein N-terminal and 11 arginine tag (11R tag) at its C-terminal in E.coli as inclusion bodies. The final product was refolded using our unique “temperature shift inclusion body refolding” technology and chromatographically purified. |
| Gene Symbol: | FIBCD1 |
| Accession Number: | NP_116232 |
| Species: | Human |
| Package Size: | 50 µg / Vial |
| Composition: | 2.0 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose, DTT and others. |
| Storage: | In Liquid. Keep at -80°C for long term storage. Product is stable at 4 °C for at least two weeks. |
| Key Reference: | Jepsen CS, et al., FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components. Front Immunol 9, 1967 (2018) Jiang C, et al., Overexpression of FIBCD1 Is Predictive of Poor Prognosis in Gastric Cancer. Am J Clin Pathol 149 (6), 474-483 (2018) von Huth S, et al., Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues. J Histochem Cytochem 66 (2), 85-97 (2018) |
| Applications: |
As human FIBCD1 Fibringen domain antigen for its specific antibody production. |
| Quality Control: | Purity: > 92% by SDS-PAGE. |
| Recombinant Protein Sequence: | MKHHHHHHQVSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITHGMDELYKSGLRSGGSGGENLYFQRSCATGSRPRDCLDVLLSGQQDDGVYSVFPTHYPAGFQVYCDMRTDGGGWTVFQRREDGSVNFFRGWDAYRDGFGRLTGEHWLGLKRIHALTTQAAYELHVDLEDFENGTAYARYGSFGVGLFSVDPEEDGYPLTVADYSGTAGDSLLKHSGMRFTTKDRDSDHSENNCAAFYRGAWWYRNCHTSNLNGQYLRGAHASYADGVEWSSWTGWQYSLKFSEMKIRPVR |